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redefining cell culture in life science

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enabling the growth of any human cell in vitro

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biologically relevant disease models for cutting edge research

enabling human biology in vitro

denovoMATRIX offers modular biomimetic matrices that can be tailored to recreate a large variety of extracellular matrices for any cell type.
easy to use

easy to use

Unpack. Seed cells. Get results.
modular

modular

Tailored environment for each cell type.
biologically relevant

biologically relevant

Meaningful results to boost research.
chemically defined

chemically defined

No batch-to-batch variation.
GxP-certifiable

GxP-certifiable

Translate research to clinics.

we are denovoMATRIX

the team

Dejan HUŠMAN
Dejan HUŠMANBioengineer, M.Sc. in Bioengineering
biomaterial engineer
Alvin THOMAS
Alvin THOMASPharmacist, Ph.D. in Chemistry
quality control scientist
Richard WETZEL
Richard WETZELBioengineer, Ph.D. in Biology
cell biology specialist
Nadine SCHMIEDER-GALFE
Nadine SCHMIEDER-GALFEBiotechnologist, MBA in Economics & Law
business developer

advisors

Robert WIEDUWILD
Robert WIEDUWILDBiologist, Ph.D. in Chemistry
Prof. Yixin ZHANG
Prof. Yixin ZHANGChemist, Ph.D. in Chemistry
Dragan GRABULOVSKI
Dragan GRABULOVSKIPharmacist, Ph.D., Co-founder Covagen

our products

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myMATRIX.
The best substrate for your cell culture.

The myMATRIX is a unique biomimetic coating, tailored to your specific application. The myMATRIX is a distinct combination of sulfated polysaccharides and biomimetic peptides, to get you the results you need.
available from May 2018

screenMATRIX.
Discover the ideal microenvironment for your application.

The screenMATRIX is the fastest way to test a large variety of factors for isolating, maintaining or differentiating your cells. screenMATRIX consists of a cell culture plate containing a different microenvironment in each cell.
available from April 2018

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Consulting services.
Let us do the heavy lifting.

We develop, characterize and manufacture extracellular matrix-mimetic coatings for all of your cell culture needs.
get in touch with us

discover YOUR cell culture solution

applications

stem cell research

stem cell research

We provide coatings tailored for pluripotency maintenance, proliferation, patterning or differentiation.

drug development

drug development

Our fully synthetic and chemically characterized coatings enable robust culture of various cell types commonly used in drug development.

tissue models

tissue models

A variety of tissue models can be recreated on our coatings, providing advantages in  model maintainance time, clarity of results and repeatable outcomes.

diagnostics

diagnostics

Our modular matrices are currently developed for use as selective expansion of cancer stem cells from heterogenous tissue extracts, with possible applications as diagnostic tools.

cell based therapies

cell based therapies

FDA approved compounds in our coatings enable their use as cell expansion platforms.

coating medical devices

coating medical devices

A challenging aspect of the application of internal medical devices is the biological interface with the body. Our chemically defined matrices permit the incorporation of bioactive compounds, and of tuning biological responses .

biomatrices created de novo for each cell type

cell types

primary cells

human HUVECs

human HUVECs

mouse hepatocytes

mouse hepatocytes

cardiomyocytes

cardiomyocytes

stem cells

mouse neuronal precursor cells

mouse neuronal precursor cells

human iPS derived neurons

human iPS derived neurons

retinal pigmented epithelial

retinal pigmented epithelial

human MSCs

human MSCs

cancer cell lines

DU-145

DU-145

Hep G2

Hep G2

HeLa

HeLa

gliobastoma multiforme

gliobastoma multiforme

immortalized cell lines

HDFn

HDFn

renal proximal tubulus epithelial cells

renal proximal tubulus epithelial cells

blood outgrowth endothelial cells

blood outgrowth endothelial cells

we mimic the cell microenvironment that determines cell fate and function

publications

Minimal Peptide Motif for Non-covalent Peptide-Heparin Hydrogels
Characterization of a cell compatible non-covalent peptide heparin hydrogel
J Am Chem Soc. 2013;135:2919–2922.

A Repertoire of Peptide Tags for Controlled Drug Release from Injectable Noncovalent Hydrogel
Noncovalent Hydrogel Beads as Microcarriers for Cell Culture
In Vivo Examination of an Injectable Hydrogel System Crosslinked by Peptide-Oligosaccharide Interaction in Immunocompetent Nude Mice

partners

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contact

+49 (0)351 4469 1538

denovoMATRIX
B CUBE - Center for Molecular Bioengineering
Technische Universität Dresden

Arnoldstr. 18
01307 Dresden
GERMANY

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