Generate clinically relevant quantities of stem cells with beadMATRIX.


Your aim is to generate clinically relevant quantities of mesenchymal stromal cells (MSCs) for cell-based therapies. You have faced difficulties upscaling your expansion process from 2D to 3D while maintaining cell quality, safety, and potency. Ideally, you would like to boost the efficiency of your manufacturing process while standardizing protocols and complying with safety regulations.


beadMATRIX are animal component-free, pre-coated microcarriers specially designed for bioreactor-scale expansion of MSCs in serum-free and xeno-free media. The coating formulation is based on the successful 2D coating product myMATRIX MSC and tailored to support customers in the establishment of translational cell therapies. Documentation describing quality and origin characteristics are provided.


  • Acceleration – expand the development capacities of your cell-based product.

  • Animal component-free – Serum-free and xeno-free 3D culture.

  • Compliant – developed in accordance with pharma grade requirements.

Large-scale production of MSCs with consistency across scales – benefit from our isoMATRIX, myMATRIX MSC and beadMATRIX product ecosystem.

Enabling outstanding yield of high quality MSCs


denovoMATRIX has carefully developed a specific coating composition and performed an elaborate optimization process to produce high-performing microcarriers for the 3D culture of MSCs. Application of beadMATRIX accelerates the proliferation of highly viable and therapeutically active MSCs up to 25% compared to the leading brand competitor. Harvested cells show MSC-specific characteristics as defined by the International Society of Cellular Therapy such as distinctive CD-marker expression and trilineage differentiation potential. In addition, they present immunomodulatory potential and angiogenic activity.

Compatible with various manufacturing processes

The upscaling of cell manufacturing is a complex topic. We aim to support the establishment and improvement of existing processes with the help of a highly compatible product. beadMATRIX has been successfully tested with different bioreactor setups and several cell culture media. Our production procedures ensure batch-to-batch consistency, product stability and compliance with the high-quality standards of ISO9001 and ISO14644. beadMATRIX documentation addresses pharma grade requirements in respect of material origin and quality. The microcarriers are sterile and ready-to-use and available in 10 gram units with larger sizes available upon request.


We develop, characterize and manufacture extracellular matrix-mimetic coatings for your applications. denovoMATRIX also offers its expertise in cell line establishment, cell expansion and cell analysis to enhance your research and development projects. Contact us for more information on our service and licensing offer.