Johnson et al. demonstrate that perlecan promotes hypertrophic growth and cardiomyocyte maturation. Perlecan inspired peptide substrate can stimulte similar behavior.
Report of a full manufacturing process from cell isolation to monolayer expansion to final small scale bioreactor setup.
Expansion of hMSC in serum-free media and a vertical wheel bioreactor enables a clinical relevant degree of proliferation while maintaining identity and potency.
First chemically defined matrix for MSC isolation.
A chemically defined functional matrix is presented and validated to support long-term culture of bone marrow-derived hMSCs in serum-free culture conditions. 2020