We have published a new Application Note in which we describe the effect of denovoMATRIX coatings on growth factors.
Growth factors are part of the cellular microenvironment and are stabilized by the cell surrounding extracellular matrix (ECM) components such as glycosaminoglycans (GAGs). Our ECM-mimetic coatings, which contain GAGs, tripled the half-life of the growth factor basic fibroblast growth factor (FGF2) in comparison to other cell culture coatings. This stabilization supported the maintenance of stemness and promoted the survival of neural precursor cells (NPCs), especially when applying restricted feeding regimes.
These results show that myMATRIX coatings improve growth factor stability and allow for reduced growth factor replenishment which reduces costs and simplifies stem cell culture.
Link to the Application Note: https://www.denovomatrix.com/wp-content/uploads/App-Note_570_growth-factors-FGF2_V01.pdf